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Acetaminophen Overdose clinical trials

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NCT ID: NCT05517668 Recruiting - Liver Failure Clinical Trials

Evaluation of the Efficacy of Fomepizole in the Treatment of Acetaminophen Overdose

Start date: September 12, 2022
Phase: Phase 2
Study type: Interventional

This study is a randomized, placebo-controlled double-blinded clinical trial of patients presenting with acetaminophen poisoning who are at increased risk of developing liver injury. With this trial the investigators are hoping to show the superiority of acetylcysteine (NAC) + fomepizole (4-MP) compared to treatment with acetylcysteine alone. The primary objective of this trial is to determine the effect of fomepizole on the severity of acute liver injury in patients with acetaminophen poisoning.