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Clinical Trial Summary

Restrictive anorexia nervosa and TOCs are psychiatric diseases which shares a common pathophysiological substrate We hypothesize that anorexia patients and patients with OCD have structural and functional changes in the accumbofrontal tract. The main objective of this study will be to compare the structure and the connectivity of this tract in MRI with diffusion sequences (DTI tractography) and resting-state, in 3 distinct populations of anorexic patients, patients with OCD and healthy patients. The role of the accumbo-frontal tract in the cortico-striato-hypothalamo-cortical circuit seems to be established. DTI tractography will allow the measurement of functional anisotropy (FA), a parameter that evaluates the diffusion of water molecules along the white matter fibers, and therefore the potential alteration of the studied tract. Resting state sequences will allow to estimate the BOLD signal and the functionality of the tract.

Clinical Trial Description


Study Design

Related Conditions & MeSH terms

NCT number NCT03496285
Study type Interventional
Source Poitiers University Hospital
Contact Benoît BATAILLE
Phone 05 49 44 45 85
Status Not yet recruiting
Phase N/A
Start date May 2, 2018
Completion date February 2019