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ABSORPTION clinical trials

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NCT ID: NCT03020680 Recruiting - Absorption Clinical Trials

Bioavailability of Ubiquinone and Ubiquinol in Older Adults

Start date: April 2016
Phase: Phase 1
Study type: Interventional

Coenzyme Q10 (or CoQ10) is a marketed supplement in US even though it can be synthesized in the body via complicated biochemical pathways. It exists in both reduced and oxidized states, namely ubiquinol and ubiquinone, respectively. It is commonly present in all cell membranes. The main function of CoQ10 is to participate in energy production. Further, the reduced form of CoQ10, ubiquinol, is appreciated as an important lipophilic antioxidant to protect free radical induced damages to DNA, lipid, and proteins. Given that older adults have increased production of free radicals, suboptimal antioxidant defenses toward free radicals, and a decreased capability to replenish utilized CoQ10, CoQ10 supplementation can be one of feasible ways to increase CoQ10 status in order adults. Most supplements available for consumers are in the oxidized form. While the ubiquinol form is also available, whether the reduced form will be more effective to replenish CoQ10 status in older subjects remains to be explored. Thus, investigators aimed to examine whether ubiquinol will be more effectively absorbed in older adults with a low antioxidant defense status. To pursue this aim, investigators will conduct a double blind, randomized, crossover design trail with 5 study visits (1 screening visit and 4 study visits). Ten older men (>55 y, BMI: 25-5 kg/m2) with a compromised antioxidant defenses will be recruited and complete the trial. Eligible subjects will be randomized to receive 200 mg/d ubiquinol or ubiquinone for 2 weeks with 2-week washout between crossover. Ubiquinol and ubiquinone in plasma and immune cells in blood will be assessed to reveal whether the reduced form, ubiquinol, is more absorbable than the oxidized form, ubiquinone in older adults.

NCT ID: NCT01185769 Completed - Absorption Clinical Trials

Study of Tocotrienol Absorption and Distribution Under Different Fat Status

Start date: September 2009
Phase: N/A
Study type: Interventional

Despite the emerging interest in tocotrienols, the absorption of tocotrienols in humans remains unclear especially with different fat diets.This study aimed at evaluating the absorption and distribution of tocotrienols in plasma and lipoproteins in associations with high and low fat diets. Different fat level will affect the absorption and distribution of tocotrienols

NCT ID: NCT00940641 Suspended - Metabolism Clinical Trials

Assess the Absorption, Distribution, Metabolism and Excretion of AZD7325 After Intravenous and Oral Administration

Start date: August 2009
Phase: Phase 1
Study type: Interventional

The purpose of this study is to evaluate the absorption, distribution, metabolism and excretion of AZD7325 after intravenous and 14C labeled oral dose

NCT ID: NCT00881062 Completed - METABOLISM Clinical Trials

Investigate Absorption, Metabolism and Excretion of [14C}-Proellex Following Single Oral Dose in Healthy Females

Start date: April 2009
Phase: Phase 1
Study type: Interventional

This study was to determine the ADME and metabolites of Proellex following a single oral dose of 25 mg.

NCT ID: NCT00638079 Completed - Pharmacokinetics Clinical Trials

Evaluating the Effect of Food on Absorption of Megace ES

Start date: June 2006
Phase: Phase 1
Study type: Interventional

To evaluate the effect of food on the rate and extent of absorption of megestrol acetate 625 mg/5 mL , and determine the safety and tolerability of megestrol acetate 625 mg/5 mL in healthy individuals.