Cervical Priming Before Dilation & Evacuation

Status Completed

Clinical Trial Summary

The purpose of this study is to compare the efficacy of buccal misoprostol cervical priming to laminaria priming among women undergoing D&E at 13-20 weeks gestation in the Western Cape Province, South Africa

Clinical Trial Description

As misoprostol is increasingly being used for cervical preparation, concerns about its use and about the proportion of women expelling the fetus prior to the D&E and other side effects mean that rigorous data on possible advantages of osmotic dilators are needed. To address this gap in the literature, we propose to perform an RCT comparing two methods of cervical preparation prior to D&E:

1. Misoprostol 400 mcg administered buccally approximately 3-6 hours prior to D&E, repeated once 3 hours after the first dose (a modified version of the current protocol)

2. Laminaria tents inserted into the cervix 18 to 24 hours prior to D&E ;

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Caregiver), Primary Purpose: Treatment

Related Conditions & MeSH terms

Abortion, Induced

Clinical Trial Details

NCT number	NCT01597726
Study type	Interventional
Source	Ibis Reproductive Health
Contact
Status	Completed
Phase	N/A
Start date	May 2012
Completion date	June 2013

View Details

See also
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