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Abortion, Habitual clinical trials

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NCT ID: NCT05365464 Withdrawn - Clinical trials for Recurrent Pregnancy Loss Without Current Pregnancy

HOPE Trial hCG or Progesterone Effect on Recurrent Pregnancy Loss

HOPE
Start date: May 2022
Phase: Phase 2
Study type: Interventional

Up to half of all cases of recurrent pregnancy loss are unexplained (uRPL). Evidence points towards endometriosis and progesterone resistance as an underlying cause of uRPL. Previous non-RCT studies have suggested the luteal hCG provides a useful treatment for uRPL. We propose performing a randomized controlled trial to compare mid-luteal hCG with oral progesterone to prevent early pregnancy losses. the endpoint will be ongoing pregnancy and live birth rates. Equal numbers of patients will be randomized to each group.

NCT ID: NCT01718340 Withdrawn - Abortion, Habitual Clinical Trials

Effectiveness of Metformin in Recurrent Miscarriage in a Woman With Hyperinsulinaemia

MetRPL
Start date: June 2012
Phase: Phase 4
Study type: Interventional

The prevalence of insulin resistance is increased in women with recurrent miscarriage compared with matched fertile controls,Insulin resistance (IR) in this syndrome is not only implicated toward early pregnancy loss (EPL) but also pathognomic for various obstetrical complications during pregnancy.An elevated free androgen index appears to be a prognostic factor for a subsequent miscarriage in women with recurrent miscarriage. There is insufficient evidence to evaluate the effect of metformin supplementation in pregnancy to prevent a miscarriage in women with recurrent miscarriage.