Abnormal Uterine Bleeding Clinical Trial
Official title:
Efficiency of Oral Etoricoxib Versus Intravenous Fentanyl On Post Operative Pain In Curettage Under TIVA : A Randomized Controlled Trial
Comparison of the efficiency of oral Etoricoxib versus intravenous Fentanyl on post operative Pain in curettage under TIVA: A randomized controlled trial
Fractional Curettage is the most widely used for diagnostic and treatment abnormal uterine
bleeding. The patient categorize post-operative pain as mild to moderate. Therefore, the
effective analgesic added on intraoperative and post-operative is the most important factor
in patient's satisfaction, patient well co-operation, shortness time of operation, decrease
unpleasant symptoms and rapid recovery. However, there are many anesthetic technique that can
be used to relive pain in the operation such as local anesthesia, total intravenous
anesthesia, regional anesthesia or oral analgesic drugs.
Intravenous Fentanyl is an short acting opioid. It has a fast onset of action within 2
minutes and short duration of action 30-60 minutes. Respiratory depression, hypotension and
bradycardia are adverse effects that might delayed discharge especially in one day surgery
e.g. fractional curettage. Etoricoxib is an oral COX-2 specific inhibitor which can be used
to relieve the pain. The onset of analgesia can be occurred within 24 minutes which peak
plasma level within 60 minutes. There are many empirical evidences to support the results of
post-operative pain after used oral Etoricoxib or intravenous Fentanyl. However, there are
less evidences to support efficiency of oral Etoricoxib versus intravenous Fentanyl on
post-operative Pain in fractional curettage under TIVA
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