Aberrant DNA Methylation Clinical Trial
Official title:
Epigenesis in Humans: Can Maternal Methyl-donor-deficient Diets Induce Epigenetic Alterations in Their Offspring?
Accumulating evidence suggests that early-life nutrition can affect metabolism and thus
increase the risk of disease in adulthood (e.g. type II diabetes and obesity). One possible
mechanism to explain these effects is epigenetic variation at critical periods of
development. Epigenetic variation describes non-inherited permanent alterations to an
individuals DNA.
Recent work in mouse models has demonstrated that maternal nutritional status can affect
such epigenetic processes such as DNA methylation and gene expression during embryonic
development, with profound effects on outcomes. The investigators aim to study these
processes in humans for the first time. The investigators will exploit the "experiment of
nature" setting in The Gambia, i.e. fluctuation in diet according to season. During the
'hungry' season diets are known to be depleted in nutrients required for epigenetic gene
regulation. Nutritional biomarkers in blood as well as the dietary intake will be measured
in pregnant women according to season. A blood sample will also be taken from babies born to
these women to determine whether there is a direct effect of diet on mothers' nutritional
status and hence variation in DNA methylation patterns in their babies by season.
n/a
Observational Model: Cohort, Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04830618 -
Aberrant DNA Methylation to Predict Metachronous Gastric Neoplasms
|
||
| Recruiting |
NCT02928120 -
Diagnostic Potential of Hypermethylated DNA in Colorectal Cancer
|
N/A |