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Abdominal Surgery clinical trials

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NCT ID: NCT03073811 Recruiting - Malnutrition Clinical Trials

Nutritional Perihabilitation in Older Veterans Undergoing Surgery

Start date: June 20, 2017
Phase: N/A
Study type: Interventional

This research study will be conducted in two parts. The first part will consist of selecting appropriate screening and assessment tools for Veterans undergoing elective surgery and identifying the number of Veterans who are malnourished and at risk of malnutrition. The second portion of the study will be to determine if a protein-enhanced diet before and after surgery will improve function and postoperative outcomes and compare the results to an education control group.

NCT ID: NCT02817893 Active, not recruiting - Abdominal Surgery Clinical Trials

Comparison of Respiratory Variations of the Pulse Oximetry Plethysmographic Raw Signal and Pulse Pressure During Abdominal Surgery (PLETHYSMO)

PLETHYSMO
Start date: October 2015
Phase: N/A
Study type: Observational

The waveform plethysmographic signal can be used to establish an index for predicting fluid responsiveness (∆POP: respiratory variation of the plethysmographic waveform of pulse oximetry). This index was validated in some studies and because of its non-invasiveness it seems very interesting in anesthesia. However, in a previous study the investigators evaluated the correlation between the results provided by this index (∆POP) and those of the reference index (∆PP: pulse pressure variation), and the obtained results were significantly lower than what had been previously described. In this study, the index was calculated from a recording of a filtered signal. This unavoidable application of a filter on anesthesia monitors could contribute to the discrepancy between the ∆POP and the ∆PP. The realization of a new study, comparing ∆PP and ∆POP obtained from an unfiltered plethysmographic signal, should answer the ∆POP ability to be used in place of ∆PP.

NCT ID: NCT01839617 Recruiting - Cancer Clinical Trials

Study Comparing Early and Late Nutrition in Cancer Patients Undergoing Abdominal Surgery

PaNCS
Start date: May 2013
Phase: Phase 3
Study type: Interventional

The aim of this study is to find which is the best nutritional strategy in cancer patients undergoing abdominal surgery regarding postoperative complications.

NCT ID: NCT01823497 Active, not recruiting - Thoracic Surgery Clinical Trials

Parent/Nurse Controlled Analgesia in the Neonatal Intensive Care Unit

PNCA
Start date: April 2013
Phase: N/A
Study type: Interventional

The aim of this study is to examine the safety and effectiveness of 2 morphine delivery systems for post-surgical neonates. The investigators hypothesize that this study will be feasible to conduct, and that neonates receiving morphine via a Parent/Nurse Controlled Analgesia pump will receive less morphine and experience fewer side effects than neonates receiving morphine via continuous opioid infusion.

NCT ID: NCT01611376 Completed - Abdominal Surgery Clinical Trials

Impedance Cardiography During Major Abdominal Surgery

Start date: September 2012
Phase: Phase 4
Study type: Interventional

The investigators validated ICG's(impedance cardiography) usefulness during the abdominal surgery, by comparing it with FloTrac/Vigileo™ (Edwards Lifesciences,Irvine, CA, USA)

NCT ID: NCT01528943 Not yet recruiting - Abdominal Surgery Clinical Trials

Effect of Prostacyclin on Haemostasis in Abdominal Surgery

Start date: March 2012
Phase: Phase 1
Study type: Interventional

The purpose of this study is to investigate the effect of continuous perioperative infusion of prostacyclin on haemostasis and endothelial functionality in patients undergoing major abdominal surgery.

NCT ID: NCT01424150 Active, not recruiting - Abdominal Surgery Clinical Trials

REstrictive Versus LIbEral Fluid Therapy in Major Abdominal Surgery: RELIEF Study

RELIEF
Start date: July 2013
Phase: Phase 4
Study type: Interventional

The optimal fluid regimen, haemodynamic (or other) targets and fluid choice (colloid or crystalloid) for patients undergoing major surgery are based on rationales that are not supported by strong evidence. Practices vary substantially, guidelines are vague, small trials and meta-analyses are contradictory. The strongest and most consistent evidence, and biological plausibility because of tissue edema, supports a restrictive fluid strategy. But other evidence supports goal-directed therapy, requiring additional IV fluid. There is no good evidence that use and choice of colloids improves outcome. RELIEF will study the effects of fluid restriction, and the possible effect-modification of goal-directed therapy and colloids. The first will be randomly assigned; the latter will be measured covariates dictated by local practices and beliefs. Study Hypotheses A restrictive fluid regimen for adults undergoing major abdominal surgery leads to reduced complications and improved disability-free survival when compared with a liberal fluid regimen. Secondary hypothesis: The effects of fluid restriction are similar whether or not goal-directed therapy is used (assessed as a statistical test of interaction). A restrictive fluid regimen will reduce a composite of 30-day septic complications and mortality.

NCT ID: NCT01389648 Completed - Abdominal Surgery Clinical Trials

Pre-operative Physiotherapy to Prevent Post-operative Complications

Start date: November 2011
Phase: N/A
Study type: Interventional

The purpose of this study is to assess the roll of pre-operative chest physiotherapy, in addition to the usual care given after major abdominal surgery, in the prevention of post-operative respiratory complications.

NCT ID: NCT01052012 Completed - Postoperative Pain Clinical Trials

Bupivacaine Effectiveness and Safety in SABER™ Trial

BESST
Start date: December 2009
Phase: Phase 3
Study type: Interventional

This is a research study testing SABER™-Bupivacaine (an experimental pain-relieving medication). SABER™-Bupivacaine is designed to continuously deliver bupivacaine, a common local anesthetic, for a few days in order to treat local post-surgical pain. The purpose of this study is to investigate safety (side effects) associated with the use of SABER™-Bupivacaine and how well it works in reducing pain and opioid-related side effects following various kinds of abdominal surgeries.

NCT ID: NCT01007487 Completed - Wound Infection Clinical Trials

Plastic Wound Retractors and Bacterial Translocation in Abdominal Surgery

Start date: January 2008
Phase: N/A
Study type: Observational

Hypothesis: Plastic wound retractors reduce passage of bacteria from the abdomen to the surgical incision site in abdominal surgery Currently, plastic wound retractors are used in abdominal surgery to facilitate access to the abdominal cavity. This study aims to establish whether they also prevent bacteria crossing from the abdominal cavity to the surgical incision site. Patients undergoing abdominal surgery in which a plastic wound retractor (Alexis®)is used are eligible for inclusion in the study. Swabs are taken from the inside and the outside of the plastic wound retractor prior to removing the retractor from the abdomen. The bacterial flora from swabs taken inside and outside the plastic wound protector are then compared to see if there is any difference between inside and outside the retractor. Bacteria are classified as 'enteric'(i.e. from the gastrointestinal tract) or 'skin' bacteria, depending on their usual location. The study aims to establish whether a plastic wound retractor (Alexis®) reduces translocation of enteric bacteria to the surgical incision site.