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What is a clinical trial?

Although there are many definitions of clinical trials, they are generally considered to be biomedical or health-related research studies in human beings that follow a pre-defined protocol. We have both interventional & observational types of studies. Interventional studies are those in which the research subjects are assigned by the investigator to a treatment or other intervention, and their outcomes are measured. Observational studies are those in which individuals are observed and their outcomes are measured by the investigators.

Current & upcoming clinical trials - Updated 4/26/2015
April 2015 - December 2019
Phase 1 (ADXS11-001 + MEDI4736 Combination Therapy) Phase 1 will be a dose-confirmation safety run-in of ADXS11-001 and MEDI4736 combination therapy. Mandatory fresh biopsies will be obtained pre- and during treatment. Phase 2: 48 subjects will be randomized 1:1:2 to receive ADXS11-001 monotherapy, MEDI4736 monotherapy or ADXS11 001 + MEDI4736 combination therapy. Arm A: ADXS11-001 Monotherapy: Arm B: MEDI4736 Monotherapy: Arm C: ADXS11-001 + MEDI4736 combination therapy
Sponsor: Advaxis, Inc.
Study type: Interventional
April 2015 - August 2016
In this study, effects of ?dT cells on human breast cancer (her2-, er-,pr-) in combination with tumor reducing surgery, for example cryosurgery going to be investigated.
Sponsor: Fuda Cancer Hospital, Guangzhou
Study type: Interventional
April 2015 - March 2017
Background: - Some people with gastrointestinal or ovarian cancer also have ascites. That is free fluid built up in the abdomen. Researchers want to see if a new drug can affect some of the immune cells in the ascites. This may also treat the cancer. Objective: - To look at the immune markers the ascites of people with gastrointestinal or ovarian cancer. Eligibility: - Adults age 18 and older with a malignancy of the GI tract or metastatic ovarian cancer. As a result, they have ascites in the abdomen. Design: - Participants will be screened with: - Medical history, physical exam, and blood tests. - Echocardiogram: sound waves make images of the heart. - Electrocardiogram: measures electrical activity of the heart. - Paracentesis: a needle will be inserted in the abdomen and will remove some of the ascites fluid. - They may have a tumor biopsy. - Participants will get AZD9150 through a vein for 3 hours. They will get this 6 times in cycle 1 and 4 times all other cycles. Each cycle is 28 days. - Each cycle, participants will: - Have a physical exam. - Have blood tests weekly. - Be asked about how they feel and any medicines they are taking. - After every 2 cycles (about every 2 months), participants will have scans and x-rays of their tumor. - Participants will have paracentesis 2 more times during the study. They will have another echocardiogram. - At the end of therapy, participants will have a physical exam and blood tests. They will be asked about how they feel and any medicines they are taking.
Sponsor: National Institutes of Health Clinical Center (CC)
Study type: Interventional
April 2015 -
The goal of this clinical research study is to learn if BMN 673 can help to control breast cancer that has a BRCA mutation. The safety of BMN 673 will also be studied.
Sponsor: M.D. Anderson Cancer Center
Study type: Interventional
April 2015 - November 2015
This study evaluates the efficacy of a stress-focused tailored weight loss intervention compared to a standard weight loss intervention on weight loss in severely obese (BMI > 40.0) African American women.
Sponsor: University of North Carolina, Chapel Hill
Study type: Interventional
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