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What is a clinical trial?

Although there are many definitions of clinical trials, they are generally considered to be biomedical or health-related research studies in human beings that follow a pre-defined protocol. We have both interventional & observational types of studies. Interventional studies are those in which the research subjects are assigned by the investigator to a treatment or other intervention, and their outcomes are measured. Observational studies are those in which individuals are observed and their outcomes are measured by the investigators.

Current & upcoming clinical trials - Updated 9/28/2014
September 2014 - November 2016
The cause of Chemotherapy-Induced Peripheral Neuropathy (CIPN) is still unknown. A theory is that the microtubule-stabilizing agents that prevent division of cells also affect healthy peripheral nerves. Symptoms of CIPN are in the hands/feet and include: pain, numbness, and loss of function. An estimated 55-60% of patients will experience lasting symptoms affecting function for years post-treatment. Research on nerve disorders identifies that a nerve already entrapped/damaged at one site may be at greater risk when combined with chemotherapy (double crush syndrome). Physical therapy is an established, effective treatment for entrapped nerves and neuropathic pain. This study seeks to identify additional risk factors and provide evidence for the role of physical therapy in the treatment of CIPN. Hypotheses 1. Physical therapy will assist in managing symptoms (sensory, pain, edema) compared to the control group during chemotherapy. 2. Positive tests for mechanical entrapment prior to chemotherapy will result in more severe symptoms of CIPN. 3. The treatment group will have greater resolution of CIPN symptoms compared to control at the six month follow-up.
Sponsor: CancerCare Manitoba
Study type: Interventional
September 2014 - October 2015
This trial is conducted in the United States of America (USA). The aim of the trial is to investigate safety, tolerability and pharmacokinetics (the exposure of the trial drug in the body) for single doses of NNC9204-0530 alone and in combination with liraglutide in overweight to obese but otherwise healthy male subjects.
Sponsor: Novo Nordisk A/S
Study type: Interventional
September 2014 - July 2017
This is an open label Phase II study to evaluate the clinical activity of the combination of gemcitabine and nab-paclitaxel (abraxane) as second line treatment in patients with metastatic pancreatic cancer who have received non-gemcitabine-based chemotherapy in the first line setting. All patients will receive both drugs on Days 1, 8, 15 every 28 days. The hypothesis is that this combination will have a 4-month progression free survival of 70% or higher.
Sponsor: Georgetown University
Study type: Interventional
September 2014 - August 2020
The investigators are creating a data and specimen repository to study causes , early detection, prevention and treatment of colon and rectal cancer. The investigators are collecting data and specimens (blood, stool, urine and tissue) from people who have colon or rectal cancer, or who are risk for developing colorectal cancer or had normal colonoscopies. Data and samples are held in the repository until there are enough to be used for a large study or until there are new techniques that can be used to test them. The GI SPORE Program at the University of Michigan maintains a repository of specimens for colorectal diseases that the investigators hope will help fuel new research. The investigators hope that this work may lead to new treatments or earlier detection of colorectal cancer or improved diagnosis and treatment of other colon and rectal diseases.
Sponsor: University of Michigan
Study type: Observational
September 2014 -
This study has several purposes. DCE-MRI will be used to image the tumor. Safety of cetuximab given before surgery will be studied. Cetuximab delivery to the tumor will be studied. In Stage 2 of this study, the safety of cetuximab and PEGPH20 given before surgery will be studied. Also, the effects of PEGPH20 on tumors will be studied.
Sponsor: Memorial Sloan-Kettering Cancer Center
Study type: Interventional
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